Skip to content
Streambay

When does Grey's Anatomy Season 5 come out?

Grey's Anatomy Season 5 premiered Thursday, September 25, 2008 on ABC and ended Thursday, May 14, 2009. The season has 24 episodes.

Live for the moment. Dive deeper into the lives and loves of "Grey's Anatomy"! The doctors struggle and thrive as they enter uncharted territories of life. Discover what happens in the on-again, off-again world of Derek and Meredith, and witness the budding relationship between Cristina and Owen, Seattle Grace's newest doctor.

Last updated

Grey's Anatomy Season 5 release schedule

Grey's Anatomy Season 5 episode release dates
Episode Release date

1. Dream a Little Dream of Me (1)

As Meredith and Derek begin to find that their "happily ever after" is anything but easy, Cristina develops a crush on a military doctor who brings in a trauma patient. Meanwhile, the Chief and his staff cope with the news that Seattle Grace is no longer considered a top-tier teaching hospital.

Thursday · 18 years ago

2. Dream a Little Dream of Me (2)

Alex is offended when Izzie talks about how great a man Alex is to Meredith. Derek is stabbed with the scalpel in the palm of his hand by Rose, while the Chief is stunned over Mercy West's increase in the number of patients, a deadly ice storm ravages Seattle.

Thursday · 18 years ago

3. Here Comes the Flood

When the plumbing springs a leak, chaos breaks out at Seattle Grace as the Chief tries to put in place new teaching methods. Meanwhile, George takes his residency exam; and Derek attempts to get Meredith's roommates to move out, much to their surprise.

Thursday · 18 years ago

4. Brave New World

Meredith is sent into a state of panic when Derek finds her mother's diary in the house. Meanwhile, Callie stresses while preparing for her first date with Erica. Later, Cristina stumbles across a part of the hospital no one has ever seen before.

Thursday · 18 years ago

5. There's No 'I' in Team

Bailey heads up a "domino procedure" in which each surgery hinges on the one preceding it. Meanwhile, Derek gets sole credit for the brain-tumor study he did with Meredith; Lexie tries to get George to notice her romantically; and Sloan counsels a desperate Callie in the ways of love.

Thursday · 18 years ago

6. Life During Wartime

The chief gives Bailey new power and responsibility. He also gives her a very difficult surgical assignment: remove a girl's inoperable tumor. Meanwhile, new trauma chief Owen (Kevin McKidd) challenges the attendings' methods and the residents' skills.

Thursday · 18 years ago

7. Rise Up

When the Chief makes an announcement that a solo surgery is up as an award, the residents are sent into a frenzy all trying to get an edge over one another. Meanwhile, Derek asks Bailey for advice after Cristina continues to interfere in his relationship with Meredith. Elsewhere, Erica uncovers a shocking connection between a resident and a patient.

Thursday · 18 years ago

8. These Ties That Bind

One of Meredith's oldest friends, Sadie, becomes an intern at Seattle Grace, but Mer's friends are less-than-welcoming to her.

Thursday · 17 years ago

9. In the Midnight Hour

Meredith, Cristina and Bailey come to Lexie and Sadie's rescue when a routine surgery goes horribly wrong, as Owen and Derek treat a man seriously injured while sleepwalking and Mark comforts the sleepwalker's distraught daughter.

Thursday · 17 years ago

10. All by Myself Mid-season finale

Cristina is awarded the first solo surgery among the residents, but she is forced to give it up and choose her replacement; Lexie is impressed when Mark performs a cutting-edge procedure; Callie doesn't know if Sadie is friendly or flirtatious.

Thursday · 17 years ago

11. Wish You Were Here

Bailey teams with Seattle Grace's new pediatric surgeon, Dr. Arizona Robbins, to save the life of a young patient near and dear to her heart, as the admittance of a death row inmate at the hospital stirs anger in Derek and further erodes Meredith and Cristina's friendship; meanwhile, Callie and Sloan work as a team to fight their respective attractions to Sadie and Lexie, and Izzie tells Alex that she's seeing Denny.

Thursday · 17 years ago

12. Sympathy for the Devil

Derek's mother, Carolyn, makes a surprise visit to Seattle and meets Meredith for the first time, as Mark tries to conceal his relationship with Lexie from her as well; meanwhile, death row inmate William wishes to donate his organs to Bailey and Arizona's patient, as Owen and Cristina try to go on their first date.

Thursday · 17 years ago

13. Stairway to Heaven

Bailey grows desperate as a patient's condition becomes more and more dire. Everyone in the hospital is stepping up to try to find the boy a new organ donor, including Meredith, who considers a death row patient's wish to die before execution. Meanwhile, an injury leaves Mark in a compromising position in the OR and Cristina awkwardly avoids Owen.

Thursday · 17 years ago

14. Beat Your Heart Out

Now that Derek has the engagement ring, he searches for the perfect way to propose to Meredith, as Lexie demands that Mark go public with their relationship, and Bailey, encouraged by her work on recent cases and by Dr. Dixon, considers a new direction for her medical career.

Thursday · 17 years ago

15. Before and After

Addison, Naomi and Sam rush the ailing Archer to Seattle Grace and reunite with old friends Derek and Mark to help save his life; meanwhile, Izzie employs her fellow doctors in a medical game designed to help teach the interns, and Owen runs into a significant someone from his past

Thursday · 17 years ago

16. An Honest Mistake

Derek's confidence is shaken like never before as he faces off with Addison over what course is best for their dying pregnant patient; Cristina calls the abilities of a renown surgeon into question after she botches a standard procedure; and Bailey, who has decided to pursue a fellowship in Pediatrics, is appalled by the Chief's less-than-stellar recommendation letter.

Thursday · 17 years ago

17. I Will Follow You Into the Dark

Derek decides to quit after learning that more of his patients have died than survived; Izzie's interns make an unsettling discovery about "Patient X."

Thursday · 17 years ago

18. Stand By Me

After his fellow surgeons try and fail to bring Derek back to work, Meredith must summon the strength to convince him. Meanwhile the hospital is abuzz as Mark attempts a rare face transplant surgery. Cristina, at last awarded her first solo surgery, is more focused on the needs of her friends, and Izzie does her best to keep her medical condition a secret.

Thursday · 17 years ago

19. Elevator Love Letter

All eyes are on Derek as he is set to perform his first surgery after his breakdown; attention is also set on Izzie, whose medical condition requires her to undergo a difficult surgery; and Owen has another PTSD episode that injures Cristina and traumatizes both of them, throwing the future of their relationship into question.

Thursday · 17 years ago

20. Sweet Surrender

As she endures aggressive treatment for her cancer, Izzie throws herself into planning Derek and Meredith's wedding.

Thursday · 17 years ago

21. No Good at Saying Sorry (One More Chance)

As preparations continue for Meredith and Derek's wedding, Izzie receives a surprise hospital visit from her handful-of-a-mother, Robbie. Meanwhile, a newly sober Thatcher visits his daughters, Meredith and Lexie, in order to make amends, and the Chief and Meredith bitterly fight over a controversial medical case.

Thursday · 17 years ago

22. What a Difference a Day Makes

As Meredith, Derek and all of their friends prepare for the big wedding, a group of college students, injured in a car crash as they were heading to their graduation ceremony, is admitted to the ER. Meanwhile, Izzie fears the worst when she begins experiencing familiar symptoms.

Thursday · 17 years ago

23. Here's to Future Days

In the first part of the two hour season finale, Izzie spends time with a fellow cancer patient and contemplates whether or not to undergo a risky surgery, as Mark is ready to take his relationship with Lexie to the next level and a patient makes Owen reassess his place at Seattle Grace.

Thursday · 17 years ago

24. Now or Never Finale

In the second part of the two hour season finale, George delivers stunning news to Bailey, sending shockwaves throughout the hospital, and Izzie's friends anxiously await her recovery from surgery. Meanwhile Bailey is surprisingly displeased after being accepted into the pediatric fellowship program, and the victim of a near-fatal traffic accident brings the talents of Seattle Grace's doctors together. This is the second hour of a 2-hour season finale.

Thursday · 17 years ago

Grey's Anatomy Season 5 guest stars

  • Jessica Capshaw

    Jessica Capshaw

    Arizona Robbins

  • Kate Walsh

    Kate Walsh

    Addison Montgomery

  • Brooke Smith

    Brooke Smith

    Erica Hahn

  • Zach Gilford

    Zach Gilford

    Charlie Lowell

  • Loretta Devine

    Loretta Devine

    Adele Webber

  • Jeff Perry

    Jeff Perry

    Thatcher Grey

  • Steven W. Bailey

    Steven W. Bailey

    Joe

  • Greta Sesheta

    Greta Sesheta

    Shayna

  • Scott Haven

    Scott Haven

    Randy Begler

  • Mac Brandt

    Mac Brandt

    Paramedic

  • Héctor Elizondo

    Héctor Elizondo

    Carlos Torres

  • Robin Pearson Rose

    Patricia Murphy

  • Gloria Garayua

    Gloria Garayua

    Intern Graciella

  • Moe Irvin

    Moe Irvin

    Nurse Tyler Christian

  • Mark Saul

    Mark Saul

    Steve

  • Kate Anthony

    Kate Anthony

    Nurse Kate

Grey's Anatomy Season 5 FAQ

When does Grey's Anatomy Season 5 come out?

Grey's Anatomy Season 5 premiered Thursday, September 25, 2008 on ABC.

How many episodes are in Grey's Anatomy Season 5?

Grey's Anatomy Season 5 has 24 episodes.

Are new episodes of Grey's Anatomy Season 5 released weekly?

New episodes are released weekly.

When is the Grey's Anatomy Season 5 finale?

The Grey's Anatomy Season 5 finale (Episode 24) aired Thursday, May 14, 2009.

How do I get notified when new Grey's Anatomy Season 5 episodes are released?

Download the Streambay app and follow Grey's Anatomy. You'll get a push notification the moment each new episode is out.

Never miss Grey's Anatomy Season 5.

Download Streambay and follow Grey's Anatomy. We’ll notify you the moment Season 5 is released, and as each new episode comes out. It’s free, with no sign-up and no personal information required.

Coming soon to App Store Get it on Google Play