Extreme Weight Loss

Krista, 34, a devoted mother whose care for her developmentally-disabled daughter has taken a tremendous toll on her 445-pound body.

Staci, 30, a 456-pound married mom caring for her husband and their two young children, while doing her best to keep a positive outlook.

Wally, 26, a young father who weighs 490 pounds and whose wife is uncertain if her husband will be around to see their daughter grow up.

A young woman works to lose weight and in the process must face the secret that lead to her becoming obese

Weighing in at 651 pounds, James, a 25-year-old former football player from Fort Worth, Texas, becomes the most obese person trainer and transformation specialist Chris Powell has ever worked with. James must lose 150 pounds to stay on track in the first of his four, three-month phases of weight loss.

45-year-old bachelor Dana tries to lose weight and reclaim his life.

A 23-year-old man tries to fulfill a promise he made to his late mother to lose weight and lead a healthier life.

An ambitious 21-year-old woman who weighs nearly 400 pounds embarks on a one-year challenge in hope of losing weight.

A 543-pound man works to get healthy so he can be a better father and husband; the Harlem Globetrotters host a day of physical challenges.

Chris helps a woman -- who blames her obesity for her daughter's death -- to get healthy.

An adopted woman named Meredith tries to reach her goal weight of 155 pounds and gain the confidence to contact her birth mother; Meredith receives a visit from actress Nicole Eggert.

Twins David and Rebecca are split up as they tackle a 90-day weight-loss challenge.

Hannah, a successful career woman who weighs 310 pounds, seeks help after learning she is too heavy to have children; racing legend Mario Andretti makes a special appearance.

A one-time fit athlete, who added more than 100 pounds after her baby suffered brain damage from Shaken Baby Syndrome, hopes to lose her excess weight and, also, gather the strength to forgive the nanny who forever changed her and her child's lives.

A 262-pound, 53-year-old woman who is also a hoarder is helped.

Hannah, a successful career woman who weighs 310 pounds, seeks help after learning she is too heavy to have children; racing legend Mario Andretti makes a special appearance.

A former professional football player who weighs 531 pounds wants to get in shape before meeting the son he didn't know he had; a 313-pound camp counselor named Panda feels out of place in his adopted family.

Born with a winning spirit, Rachel began dancing at three years old. As Rachel grew older, her spirit was hampered by mixed feelings towards love, sex and religion, so she turned to food for emotional support and became obese. Rachel is now looking to "get her groove back".

Tiffany, an autism activist and single mother of an autistic teenager, battles her past history of eating disorders and negative food choices so she can live a longer life and continue to parent her son.

A couple postpones their wedding so that they can lose weight. Their goal: to be able to wrap their arms around each other for their first dance.

Chris and Heidi help a formerly fit couple get back in shape for their wedding day; David Tutera, Rocco DiSpirito and Duff Goldman help the couples plan their big day.

A tragic accident inspires a 399-pound firefighter to change his life; a 331-pound former college basketball player wants to overcome her depression and reclaim her life and her health.

Avid basketball fans, twins Robert and Raymond -- who start out at 381 and 378 pounds, respectively -- get the chance to meet players Kobe Bryant, Steve Nash, Byron Scott and James Worthy along their weight loss journey.